cipher - Rendez-vous with your eccentric uncle

Your eccentric uncle is a world-renowned cryptologist and he sees in you a high potential to follow in his footsteps. You are of course very flattered and can't wait to get going with the special training program he has set up for you. Your training will commence tomorrow at a rendez-vous point that your uncle has communicated to you by means of an encrypted message. To prove that you are worthy, decrypt the message and find out where the rendez-vous will take place!

The message reads:

Note: The puzzle contains multiple layers and is best solved one step at a time. Only the message itself is needed to solve this puzzle, all the rest is just flavour text.

Since it seems to be unclear how to deal with the different layers, I will add a little hint in the form of an example here:

Say the message were: "hI, this Is a HiNT MeSsAge", then this can be seen as a combination of two layers. In one layer some characters have been capitalized: "hI, this Is a HiNT MeSsAge" and in another layer some letters where made bold and italicized (both were done at the same time, just to make the letters jump out a little more): "hi, this is a hint message".
When working on solving one layer, you can (and should) ignore all other layers. The solution will then provide a clue for the next layer. The layers must be solved in a specific order, though.

Hint for the first layer:

For the first layer the exact characters are not important, just the pattern of highlighted vs. non-highlighted characters. The solution is 43 characters long.

Hint 2:

For the first layer should be read as a binary string.

Answer

Final Answer

Rendez-vous will take place at -

CENTRAL PARK

Taking the clue from the Hint "For the first layer should be read as a binary string."

If the first layer mean - uppercase treated as 1's and lower case as 0's we get - 215 characters turned into binary as - 101001001001001100000000001000110010010101110000010000 00010100001101000000001011010011011101001000000010100001001110110000 10100000110010000110111011100000001001100100111101110010010001100000 1001110100110010110000101

Another hint says the first layer gives 43 characters hence-

We need to split the 215 binary into group of 5 to get 43 characters.

So..

Grouping them into 5-bits and checking the corresponding letter we get
10100 = 20 = T

10010 = 18 = R
01001 = 9 = I
....
We get "TRIP HYENA EAT KIWI EAGLE YAWN IRONIC STYLE" (Treating 00000 as space")

So...

Taking first letters we get - > THE KEY IS and Thanks to Ankoganit for figuring out the key. which are last letters PATIENCE

Knowing this(Thanks to @Sconibulus, @Gareth) -

PATIENCE is an 8 letter word. So, checking the pattern with bold characters we get aeybssdvxgabsstvdtmes Applying Vigenère cipher with PATIENCE as key we get LeftOFBrighTOfrrotTwo which means Left OF B(blue) righT Of r(red) rot-Two(rot-2)

Hence,

Taking the letter's left of Blue and right of Red colored ones, we get - aclrpyjnypi and applying rot-2 gives centralpark

So the rendez-vous will take place at -

Central Park

All thanks to @Gareth, @dcfyj, @Ankoganit and @Sconibulus. Would have costed a lot of brainstorming solving this one.

With that done, I would say, the solution will be too difficult without hints as the puzzle doesn't speak of what to apply where.