electromagnetism - Electric charges on compact four-manifolds

Textbook wisdom in electromagnetism tells you that there is no total electric charge on a compact manifold. For example, consider space-time of the form $\mathbb{R} \times M_3$ where the first factor is time. One defines the total charge via $Q(M_3) = \int_{M_3} \star j$ where $d\star F = \star j$ is the electric current. If $M_3$ has no boundary (e.g. if it is compact) one can use Stokes' theorem to argue that $$ Q(M_3) = \int_{M_3} d\star F = \int_{\partial M_3} \star F = 0.$$

I wonder what happens for general four-manifolds $M_4$, especially in the case that the third Betti number is zero (otherwise one can simply integrate over a three-cycle). Is there a sensible way to define charge in the above sense? Can one argue that it has to vanish if $\partial M_4 = 0$?